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Mechanism of Action

 

Understanding the mechanism of action (MOA) is fundemental to analyzing biological, physiological and organismic effects from drug efficacy and toxicity to developing potency assays. The MOA is often not described by a single event or effect, but by several events or effects that accumulate or are additive.

 

Most MOA assays are not specific, but can be applied to many different applications. For example, the different assays used to detect nanoparticle toxicity may also be described as MOA assays.

 

The following represents a partial list of MOA assays that can be applied and multiplexed with virtually all HemoGenix® assays and cell types used for those assays. If a particular assay is not shown below, please contact HemoGenix®, since we may have it available or it it could be developed for your goal. 

 

  • FloDiff™: Membrane expression marker detection, cell cycle, ploidy, apoptosis (depends on the species and cell markers available).
  • Membrane integrity: LDH and/or PI assays.
  • Micronucleus assay.
  • Soft agar assay.
  • Chemotaxis/ migration assays.
  • GFkine™: Growth factor/cytokine production/release.
  • Phospodiesterase assays.
  • Kinase assays.
  • Protease assay.
  • P-Glycoprotein assay.
  • Monoamine oxidate assay.
  • UDPglucuronosytransferase (UGT) assay.
  • Mitochondrial ToxGlo™: Mitochondrial dysfunction assay.
  • Glutathione Assay: Oxidative stress.
  • Nitric oxide (NO) assay
  • Lipid peroxidation assay
  • Reactive oxygen species assays
  • OxyFLOW™: A flow cytometric oxidative DNA damage assay.
  • Biochemical apoptosis assays: CaspaseGlo™.
  • Cytochrome P450 assays.
  • Cellular drug-drug interaction studies.

 

For more information, please contact HemoGenix directly at (719) 264-620 or info@hemogenix.com