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Mechanism of Action Studies

 

Mechanism of Action studies performed at HemoGenix 

 

 Mechanism of Action
  • FloDiff™: Membrane expression marker detection, cell cycle, ploidy, apoptosis (depends on the species and cell markers available).
  • Membrane integrity: LDH and/or PI assays.
  • Micronucleus assay.
  • Soft agar assay.
  • Chemotaxis/ migration assays.
  • GFkine™: Growth factor/cytokine production/release.
  • Phospodiesterase assays.
  • Kinase assays.
  • Protease assay.
  • P-Glycoprotein assay.
  • Monoamine oxidate assay.
  • UDPglucuronosytransferase (UGT) assay.
  • Mitochondrial ToxGlo™: Mitochondrial dysfunction assay.
  • Glutathione Assay: Oxidative stress.
  • Nitric oxide (NO) assay
  • Lipid peroxidation assay
  • Reactive oxygen species assays
  • OxyFLOW™: A flow cytometric oxidative DNA damage assay.
  • Biochemical apoptosis assays: CaspaseGlo™.
  • Cytochrome P450 assays.
  • Cellular drug-drug interaction studies.