Detecting Toxicity in Multiple Proliferating Systems Using LumiSTEM™

LumiSTEM

It is often necessary to use multiple assays with various readouts to detect toxicity to different cell types. LumiSTEM™, LUMENESC™ and HALO® all use the same ATP-based bioluminescnce signal detection system. HemoGenix® has combined its three platforms into a single, unique and extremely powerful predictive toxicity platform called ComparaTOX™ - Predictive In Vitro Cross-Platform Comparative Toxicity Testing.

The LumiSTEM™-96 or LumiSTEM™-384 Platform can incorporate and test any of the cells listed below in side-by-side assays. This is the list which HemoGenix® uses for its Contract Research Services. Despite the fact that these cell types require different culture conditions, they can all be tested for their response to toxic agents using LumiSTEM™.

  • Airway epithelial systems
    • Small airway epithelial cells
    • Bronchial/Tracheal epithelial cells
  • Bladder cell systems
    • Bladder smooth muscle
    • Bladder microvascular endothelial cells
  • Endothelial cell systems
    • Aortic
    • Coronary artery
    • Iliac artery
    • Lung microvascular
    • Adult dermal microvascular
    • Neonatal dermal microvascular
    • Pulmonary artery
    • Umbilical artery
    • Umbilical vein
    • Uterine microvascular
  • Fibroblast cell systems
    • Aortic advential
    • Peridontal ligament
    • Neonatal dermal
    • Lung
  • Epidermal keratinocyte cell system
    • Adult epidermal
    • Neonatal epidermal
  • Mammary epithelial cell system
  • Neural cell system
    • Astrocyte
  • Prostate cell systems
    • Prostate epithelial
    • Prostate stromal
    • Prostate smooth muscle
  • Renal cell systems
    • Cortical epithelial
    • Renal epithelial
    • Mesangial cells
    • Renal proximal tubule epithelial
  • Skeletal cell systems
    • Osteoblasts
    • Articular chondrocytes
  • Skeletal muscle systems
  • Smooth muscle systems
    • Aortic smooth muscle
    • Bronchial smooth muscle
    • Coronary artery smooth muscle
    • Pulmonary artery smooth muscle
    • Umbilical artery smooth muscle
    • Uterine smooth muscle.
  • Embryonic stem cells
  • Transformed cell lines, e.g. NCI Cell Line Screening Panel