In Vitro Toxicity Testing of Non-Hematopoietic and MSC Cells

LumiSTEM

 

LumiSTEM™ -

In Vitro Toxicity Testing of

Non-Hematopoietic and

Non-Mesenchymal Stem Cells

 

Conventional toxicity testing includes:

  • Hepatotoxicity
  • Neural toxicity
  • Renal toxicity
  • Lung toxicity
  • Cardiotoxicity
  • Toxicity to the reproductive organs
  • Gastrointestinal toxicity
  • Toxicity to the eye
  • Embryonic and fetal toxicity
  • Endocrine toxicity
  • Hemotoxicity

Depending on the compound or agent being tested, more emphasis will be placed on the expected or predicted toxicity. New toxicity assays and methods to predict toxicity are continually being developed. However, many forms of toxicity testing rely on surrogate in vitro techniques, often using transformed cell lines that have little or no relation to the human patient. Similarly, the use of animals to predict human toxicity is almost as difficult as using transformed cell lines instead of primary cells.

True, in vitro assays are surrogate assays for human studies, but the better an assay simulates the human situation, the more reliable and predictive the toxicity assay will become.

At HemoGenix®, we have designed and developed in vitro assays using primary human tissues with the specific intent of producing results that could help predict how human biological systems respond.