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In Vitro Toxicity Testing of
Non-Hematopoietic and
Non-Mesenchymal Stem Cells
Conventional toxicity testing includes:
Depending on the compound or agent being tested, more emphasis will be placed on the expected or predicted toxicity. New toxicity assays and methods to predict toxicity are continually being developed. However, many forms of toxicity testing rely on surrogate in vitro techniques, often using transformed cell lines that have little or no relation to the human patient. Similarly, the use of animals to predict human toxicity is almost as difficult as using transformed cell lines instead of primary cells.
True, in vitro assays are surrogate assays for human studies, but the better an assay simulates the human situation, the more reliable and predictive the toxicity assay will become.
At HemoGenix®, we have designed and developed in vitro assays using primary human tissues with the specific intent of producing results that could help predict how human biological systems respond.