MSC Potency Measurement for Storage and Transplantation
The Mesenchymal Stem Cell System and
LUMENESC™-QC Platform
for
Stem Cell Transplantation and Cord Blood
Storage Quality Control
The MSC System is, in part, responsible for the hematopoietic microenvironment otherwise known as the hematopoietic stroma. Without the hematopoietic stroma, hematopoiesis would not occur. The hematopoietic stroma consists of macrophages, reticulum cells, endothelial cells and fibroblasts. Together, they form a "stem cell niche" allowing stem cells to be maintained. The cells comprising the hematopoietic stroma produce a number of growth factors and cytokines that act locally and at very short distances. This usually occurs by growth factor or cytokine presentation to the target cells. In addition, cell-to-cell interactions are also involved. Together, a mileu is constructed that allows stem cells to be maintained and, if required, to proliferate.
It follows that if the hematopoietic stroma is damaged, for example by radiation or drugs and other chemicals, the ability to support hematopoiesis will be severely reduced or lost. HemoGenix® has developed the LUMENESC™ Quality Control (QC) assay for this purpose. It allows the content and proliferative capability of the MSC present in processed products for transplantation purposes to be detected and measured within 10 days. When combined with any of the HALO® SPC-QC assay system, especially the HALO® 7-Population SPC-QC Platform, an extremely powerful assay system is constructed that could predict short- and long-term engraftment and repopulation potential.
Please contact HemoGenix® for more information on how you might be able to improve your quality control assessment of stem cell processed products.
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