Oxidative DNA Damage
Free radical production and oxidative DNA damage have been associated with multiple organ and disease conditions including:
- Aging
- Arthritis
- Teratogenesis
- Stroke
- Neurodegenerative disorders (Alzheimer’s disease)
- Carcinogenesis
- Anti-cancer drug therapy
- Crohn’s disease
- Multiple sclerosis.
Oxidative injury to macromolecules is implicated in a wide range of these pathological conditions. Damage is mediated via free radicals that can be caused by a number of agents. The OxyFLOW™ Kit can therefore be used in a number of applications.
- Genotoxicity
- Xenobiotics
- Oxidative stress / Nutrient deficiency
- Radiation biology
- Inflammation
- Ischemia-reperfusion injury
- Effectiveness of cosmetics and sunscreen protection
- Normal metabolic activity.
The free radicals can react with DNA leading to mutation, carcinogenesis and cell death. All proliferating cells are susceptible to this type of damage and stem cells lead the list because they have the greatest proliferative potential. Damage to the stem cells results in dramatic perturbation of normal steady-state conditions and can lead to malignancy.
