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Peer-Reviewed Articles

  1. Rich IN & Kubanek B. Erythroid colony formation (CFUe) in fetal liver and adult bone marrow and spleen from the mouse. Blut (1976), 33:171-180.
  2. Opitz U, Seidel H-J & Rich IN. Erythroid stem cells in Rauscher virus infected mice. Blut. (1977), 35:35-44.
  3. Hansi W, Rich IN, Heit W, Kubanek B & Heimpel H. Erythroid colony-forming cells in aplastic anemia. Brit. J. Haematol. (1977), 37:483-488.
  4. Rich IN & Kubanek B. The ontogeny of erythropoiesis in the mouse detected by the erythroid colony-forming technique. I.Hepatic and maternal erythropoiesis. J. Embryol. exp. Morph. (1979), 50:57-74.
  5. Rich IN & Kubanek B. The ontogeny of erythropoiesis in the mouse detecetd by the erythroid colony-forming technique. II. Transition in erythropoietin sensitivity during development. J. Embryol. exp. Morph. (1980), 58:143-155.
  6. Rich IN, Heit W & Kubanek B. The effects of actinomycin D on erythropoiesis. I. Short-term effects. Blut. (1980), 41:29-40.
  7. Rich IN & Kubanek B. An erythropoietic stimulating factor similar to erythropoietin released my macrophages after treatment with silica. Blut. (1980), 40:297-303.
  8. Pentz S, Vergani G, Amthor A, Horler H & Rich IN. A method for electron microscopic preparation of cultured cells (monolayer) in a new test chamber (TCSC-1). Microscopica Acta. (1981), 84:117-120.
  9. Rich IN, Anselstetter V, Heit W, Zanjani E & Kubanek B. Release of erythropoietin from macrophages by treatment with silica. J. Supramol. Struct. & Cell. Biochem. (1981), 15:169-176. Also published in: UCN-UCLA Symposia Proceedings of Control of Cellular Division and Development. Part A. A.L. Liss, New York. (1981).
  10. Rich IN, Sawatzki G & Kubanek B. Specific enhancement of mouse CFU-E by mouse transferrin. Brit. J. Haematol. (1981), 49:567-573.
  11. Rich IN & Kubanek B. Release of erythropoietin from macrophages mediated by phagocytosis of crystalline silica. J. Reticuloendo. Soc. (1982), 31:17-30.
  12. Rich IN, Heit W & Kubanek B. Extrarenal erythropoitein production by macrophages. Blood. (1982), 60:1007-1018.
  13. Rich IN & Kubanek B. The effect of reduced oxygen tension on colony formation of erythropoietic cells in vitro. Brit. J. Haematol. (1982), 52:579-588.
  14. Lappin TRJ, I.Rich & Goldwasser E. The effect of erythropoietin and other factors on DNA synthesis by mouse spleen cells. Exp. Hematol. (1983), 11:661-666.
  15. Rich IN. Hemopoietic regulation in vitro: In vivo significance of functionally similar multiactive potentiating factors. Collection des Annales de l'Institut Pasteur, Annales D'Immunologie. (1984), 135C:280-288.
  16. Rich IN. A role for the macrophage in normal hemopoiesis: I. Functional capacity of bone arrow macrophages to release hemopoietic growth factors. Exptl. Hemat. (1986), 8:738-745.
  17. Rich IN. A role for the macrophage in normal hemopoiesis: II. Effect of varying oxygen tensions on the release of hemopoietic growth factors from bone marrow-derived macrophages in vitro. Exptl. Hemat. (1986), 8:746-751.
  18. Rich IN, Vogt Ch, Pentz S. Erythropoietin gene expression in vitro and in vivo detected by in situ hybridization. Blood Cells (1988) 14:505-520.
  19. Rich IN. Haemopoietic regulation and the role of the macrophage in erythropoietic gene expression. Adv Exp Med Biol (1988) 241:55-66.
  20. Vogt Ch, Pentz S, Rich IN. A role for the macrophage in normal hemopoiesis: III. In vivo and in vitro erythropoietin gene expression in macrophages detected by in situ hybridization. Exp Hemat (1989) 17:391-397.
  21. Sawatzki G, Rich IN. Lactoferrin stimulates colony stimulating factor production in vitro and in vivo. Blood Cells (1989) 15:371-385.
  22. Rich IN, Sawatzki G. Lactoferrin, the signal for colony stimulating factor production? Negative-feedback regulation versus supply-and-demand regulation of myelopoiesis. Blood Cells (1989) 15:400-406.
  23. Vogt Ch, Noé G, Rich IN. The role of the blood island during normal and 5-fluorouracil-perturbated hemopoiesis. Blood Cells. (1991), 17:105-125.
  24. Rich IN. The effect of 5-Fluorouracil on erythropoiesis. Blood (1991), 77:1164-1170.
  25. Rich IN. The site of erythropoietin production: Localization of erythropoietin mRNA by radioactive in situ hybridization. Blood (1991), 78:2469.
  26. Rich IN. The developmental biology of murine hemopoiesis: Effect of growth factors on colony formation by embryonic cells. Exp Hemat (1992), 20:368.
  27. Noé G, Riedel W, Kubanek B, Rich IN. A sensitive sandwich ELISA for measuring erythropoietin in human serum. Brit J Haematol (1992), 80:285.
  28. Gebicke-Haerter PJ, Appel K, Taylor GD, Schobert A, Rich IN, Northoff H, Berger M. Rat microglial interleukin-3. J Neuroimmunol (1994) 50:203
  29. Rich IN, Kubanek B. The autonomous release of erythropoietic inhibition during long-term in vivo administration of actinomycin D. Exp. Hematol. (1994) 22:347.
  30. Schrezenmeier H, Noé G, Raghavachar A, Rich IN, Heimpel H, Kubanek B. Serum erythropoietin and serum transferrin receptor levels in aplastic anaemia. Brit. J. Haemat. (1994) 88:286-294.
  31. Rich IN. Hemopoietic-initiating cells. J Perinat Med 23:31-38 (1995).
  32. Rich IN. Primordial germ cells are capable of producing cells of the hemopoietic system in vitro. Blood 86:463 (1995).
  33. Noè G, Augustin J, Hausdorf S, Rich IN, Kubanek B. Serum erythropoietin and transferrin receptor levels in patients with rheumatoid arthritis. Clin Exp Rheumatol 13:445-451 (1995).
  34. Gunga H-C, Kirsch KK, Rich IN, Rocker L. Erythropoietin after long-term spaceflight (30 d). Aviation, Space and Environ Med 66:913 (1995).
  35. Zimmermann F and Rich. The sensitivity of in vitro erythropoietic progenitor cells to different erythropoietin reagents during development and the role of cell death in culture. Exp Hemat 24:330-339 (1996)
  36. Gunga H-C, Roecker L, Behn C, Hildebrandt W, Koralewski E, Rich I, Schobersberger W, Kirsch K. Shift working at high altitude in the Chilean Andes (>3,600 m) and is influence on erythropoietin and the low pressure system. J Appl Physiol (1996)
  37. Gunga H-C, Kirsch K, Baartz F, Maillet A, Gharib C, Nalishiti W, Rich I, Roecker L. Erythropoietin under real and simulated micro-g conditions in man. J Appl Physiol (1996).
  38. Zimmermann F and Rich IN. Mammalian homeobox B6 (HOX B6) expression can be correlated with erythropoietin production sites and erythropoiesis during development, but not with hemopoietic or non-hemopoietic stem cell populations. Blood 89:2723-2735 (1997).
  39. Rich IN. Standardization of the CFU-GM assay using hematopoietic growth factors. J. Hematotherapy:6:191-192 (1997).
  40. Rich IN, Brackmann I, Dewey MJ, Worthington-White D. Activation of the sodium/hydrogen exchanger via the fibronectin-integrin pathway results in hematopoiesis stimulation. J Cell Physiol. 177:109-122 (1998).
  41. Noé G, Riedel W, Kubanek B, Rich IN. An ELISA specific for murine erythropoietin. Brit J Hematol 104:838-840 (1999).
  42. Garden OA, Musk P, Worthington-White DA, Dewey M, Rich IN. Silent polymorphisms within the coding region of human sodium/hydrogen exchanger isoform-1 cDNA in peripheral blood mononuclear cells of leukemia patients: A comparison with healthy controls. Cancer Genet and Cytogenet 120:37-43 (2000).
  43. Rich IN, Worthington-White D, Garden OA, Musk P. Apoptosis of leukemic cells correlates with reduction in intracellular pH after targeted inhibition of the Na+/H+ exchanger. Blood 95:1427-1434 (2000).
  44. Rich IN. In vitro hemotoxicity testing in drug development. A review of past, present and future applications. Current Opinion in Drug Discovery and Development. 6:100-109 (2003).
  45. Lis CG, Grutsch JF, Wood P, You M, Rich IN, Hrushesky WJM. Circadian timing in cancer treatment: The biological foundation for an integrative approach. Integrative Cancer Therapies. 2:105-111 (2003).
  46. Rich IN and Hall KM. Validation and development of a predictive paradigm for hemotoxicology using a multifunctional bioluminescence colony-forming proliferation assay. Tox Sci 87:427-441 (2005).
  47. Rich IN. High-throughput in vitro hemotoxicity testing and in vitro cross-platform comparative toxicity. Expert Opin Drug Metab Toxicol. 3:295-307 (2007).
  48. Reems JA, Hall KM, Gebru LH, Taber G, Rich IN. Development of a novel assay to evaluate the functional potential of umbilical cord blood progenitors. Transfusion. 48:620-628 (2008).
  49. Hall KM, Harper H, Rich IN. Hematopoietic Stem Cell Potency for Cellular Therapeutic Transplantation.
    (2012). Advances in Hematopoietic Stem Cell Research, Rosana Pelayo (Ed.), ISBN: 978-953-307-930-1, InTech.
  50. Patterson J, Moore CH, Palser E, Hearn JC, Dumitru D, Harper HA, Rich IN. Detecting primitive hematopoietic stem cells in total nucleated and mononucleated cell fractions from umbilical cord blood segments and units. J. Translational Medicine (2015) 13:94. http://www.translational-medicine.com/content/13/1/94.
  51. Rich IN. Improving quality and potency testing for umbilical cord blood: A new perspective. Stem Cell Translatiuonal Medicine (2015) 4/9: 967-973. http://stemcellstm.alphamedpress.org/content/4/9/967.short?rss=1.

 

Reviews and Book-Chapters

  1. Kubanek B, Heit W & Rich IN. Fetal erythropoiesis. In: Fetal Liver Transplantation. Current Concepts and Future Trends. Eds. G. Lucarelli, T.M. Fliedner & R.P. Gale. Excerpta Medica/North Holland (1980) pp 70-78.
  2. Rich IN, Anselstetter V, Heit W & Kubanek B. The role of the macrophage in extrarenal erythropoietin production and ontogeny in mouse and man. In: Fetal Liver Transplantation. Current Concepts and Future Trends. Eds. G. Lucarelli, T.M. Fliedner & R.P. Gale. Excerpta Medica/North Holland. (1980) pp 95-107.
  3. Kubanek B & Rich IN. Fetal erythropoiesis. In: Adv. Physiol. Sci. Vol 6. Genetics, Structure and Function. Eds. S.R. Holland, G. Gardos & B. Sarkodi. Pergamon Press. (1981) pp 147-151.
  4. Heit W, Rich IN & Kubanek B. Macrophage-dependent production of erythropoietin and colony-stimulating factor. In: Hematology and Blood Transfusion Vol. 27. Disorders of the Monocyte Macrophage System. Eds. F. Schmalzl, D. Huhn, H.E. Schaefer. Springer-Verlag Heidelberg. (1981) pp.73-78.
  5. Goldwasser E, Ihle JN, Prystowsky MB, Rich IN & van Zant G. The effect of Interleukin 3 on hemopoietic precursor cells. In: Normal Neoplastic Hemopoiesis. Symposium on Molecular and Cell Biology. Eds. D. Golde, P. Marks & C.F. Fox. A.L. Liss, New York. (1983) pp 301-309.
  6. Rich IN. The effect of silica on hemopoiesis: Evidence for the macrophage acting as a regulator cell. Immunology and Hematology Research. Monograph (1984), No. 3. pp.175-178.
  7. Rich IN. Macrophage-derived hemopoietic humoral factors: regulatory role of the macrophage in hemopoiesis. In: New Trends in Experimental Hematology. Oncogenes, Stem Cells, Bone Marrow Transplantation. Eds. C. Peschle & C. Rizzoli. Serono Symposia Review (1984),No. 7. pp.27-33. .
  8. Rich IN. The central role of the macrophage in hemopoietic microenvironmental regulation. In: Cronkite EP, Dainiak N, McCaffrey RP, Palek J, Quesenberry PJ (Eds), Hemopoietic Stem Cell Physiology. Alan R. Liss. New York. (1985) pp 283-300.
  9. Rich IN. The macrophage as a producer of erythropoietin: Response to physiological oxygen tensions and detection of gene expression using in situ hybridization. In: Rich IN (Ed) Molecular and Cellular Aspects of Erythropoietin and Erythropoiesis, Springe-Verlag, Heidelberg (1987) pp. 291-310.
  10. Frickhofen N., Raghavachar A., Rich I., Heit W. & Heimpel H. Inhibition of hematopoietic progenitor cells by a variant of the L1210 leukemia cell line. In: Proceedings of the 1st International Symposium on Inhibitory Factors in the Regulation of Hematopoiesis. Najman A., Guigon M., Gorin N-C., Mary J-Y. (Eds). John Libby Eurotext, London, Paris (1987) pp 213-216.
  11. Rich IN & Sawatzki G. The role of lactoferrin in regulating colony stimulating factor production. In: Proceedings of the 1st International Symposium on Inhibitory Factors in the Regulation of Hematopoiesis. (1987). Najman A., Guigon M., Gorin N-C., Mary J-Y. (Eds). John Libby Eurotext, London, Paris (1987) pp 63-67.
  12. Rich IN. Oxygen Tension and erythropoietin production: The role of the macrophage in regulating erythropoiesis. In: Oxygen Sensing in Tissues, H. Acker (ed) Springer-Verlag, (1988) pp 113-120.
  13. Rich IN, Vogt Ch. Pentz S. Erythropoietin gene expression in macrophages detected by in situ hybridization. Behring Institute Mitteilung (1988) pp. 202-206.
  14. Rich IN. The macrophage as a production site for hematopoietic regulator molecules: Normal and pathophysiological signals. Anticancer Research. (1988) 8:1015-1040.
  15. Rich IN. Erythropoietin production under steady-state conditions: Detection and localization using in situ hybridization. In: Erythropoietin, Jelkmann W, Gross AJ (Eds). Springer Verlag (1989), pp 19-25.
  16. Rich IN. Oxygen sensing mechanisms in the macrophage and erythropoietin production. In: Arterial Chemoreception, Eyzaguirre C, Fidone SJ, Fitzgerald RS, Lahiri S, McDonald D. Springer Verlag. (1990) pp. 113-120.
  17. Vogt Ch, Noé G, Rich IN. Normal steady-state hemopoiesis. Assay of erythropoietin by ELISA, localization of erythropoietin in the kidney and expression of hemopoietic regulator molecules in the bone marrow. In: Molecular Biology of Hemopoiesis. Sachs L, Abraham N, Weidermann C, Konwalinka C (Eds). Intercept Ltd. Andover, U.K. (1990) pp 401-412.
  18. Rich IN. Molecular and cellular aspects of erythropoietin and erythropoiesis --- From 1986 to 1990. In: Recent Advances in Cell to Cell Signals in Plants and Animals. Neuhoff V, Friend J (Ed). Springer Verlag, Heidelberg. NATO ASI Series H. (1991) Vol 51:118-132.
  19. Rich IN. Erythropoietin Production -- A Personal View. (Invited review) Exp Hemat (1991), 19:985-990.
  20. Rich IN & Noé G. The developmental biology of erythropoiesis and erythropoiesis. Is erythropoietin a true hormone or a paracrine factor? In: 2nd International Meeting of Erythropoietin Pathophysiology in Lübeck. (1992) pp.79-87.
  21. Noë G, Rich IN, Kubanek B. A sensitive ELISA for erythropoietin and its application in various diseases. In: 2nd International Meeting of Erythropoietin Pathophysiology in Lübeck. (1992) pp.109-116.
  22. Schrezenmeier H, Noë G, Rich IN, Raghavachar A. Serum erythropoietin levels in aplastic anemia determined by ELISA. In: 2nd International Meeting of Erythropoietin Pathophysiology in Lübeck. (1992) pp. 225-231.
  23. Ploemacher RE, Rich IN. Congress Letter. Summary of the European Stem Cell Club. Leukemia (1992) 6:1081-1082.
  24. Noé G, Schrezenmeier H, Rich IN, Kubanek B. Circulating erythropoietin levels in pathophysiological conditions. In: Molecular, Cellular and Developmental Biology of Erythropoietin and Erythropoiesis. IN Rich and TRJ Lappin (Eds). Annals of the New York Academy of Sciences (1994) 718:94.
  25. Rich IN, Riedel W, Zimmermann F, Vogt Ch, Noé G. The initiation of the hemopoietic system. The response of embryonic cells to growth factors and expression of erythropoietin and erythroid-relevant genes during murine development. In: Molecular, Cellular and Developmental Biology of Erythropoietin and Erythropoiesis. IN Rich and TRJ Lappin (Eds). Annals of the New York Academy of Sciences (1994) 718:140.
  26. Kubanek B, Rich IN, Noé G. Erythropoietin. Infusionstherapie und Transfusionsmedizin. (1994) 21:46-50.
  27. Rich IN. Hemopoietic - Initiating Cells. J. Perinatal Medicine 23 (1/2): 31-38 (1995)
  28. Lappin TRJ and Rich IN. Erythropoietin - The first 90 years. Clin. Lab Hematol 18:137-145(1996)
  29. Van Zant G, de Haan G, Rich IN. Alternative to stem cell renew from a developmental viewpoint. Exp. Hemat (Review) 25:187-192 (1997).
  30. Rich IN. Homeobox genes and hematopoiesis. J Hematotherapy 7:515-520 (1998).
  31. Rich IN. Monocytes and Macrophages. In: Human Cell Culture, Volume 4, Primary Hematopoietic Cells, MR Koller and BO Palsson (Eds). Kluwer Academic Press pp125-146 (1999).
  32. Rich IN. Predictive stem cell hemotoxicity testing. Assay Tutorial. Genetic Engineering News. 24/7:32-33 (2004).
  33. Hall KM, Harper H, Rich IN. (2012) Hematopoietic stem cell potency for cellular therapeutic transplantation. In: Hematopoietic Stem Cells, Ed. Rosana P. Camacho. Published by: InTech Open Access Publisher. ISBN 978-953-307-746-8.
  34. Harper H, Rich IN. Stem Cell Predictive Hematotoxicology. In: Stem Cell Biology in Normal Life and Diseases, Ed. Alimoghaddam K. Published by InTech Open Access Publisher. ISBM 978-953-51-1107-8. (2013).
  35. Rich IN. Short Primer in Stem Cell Biology. In: Stem Cell Protocols. Methods in Molecular Biology, 1235, Ed. Rich IN. Published by Human Press (2015).
  36. Rich IN. Measurement of Hematopoietic Stem Cell proliferation, Self-Renewal and Expansion Potential. In: Stem Cell Protocols. Methods in Molecular Biology, 1235, Ed. Rich IN. Published by Human Press (2015).
  37. Harper H and Rich IN. Measuring the Potency of a Stem Cell Therapeutic. In: Stem Cell Protocols. Methods in Molecular Biology, 1235, Ed. Rich IN. Published by Human Press (2015).
  38. Hrushesky W and Rich IN. Measuring Stem Cell Circadian Rhythm. In: Stem Cell Protocols. Methods in Molecular Biology, 1235, Ed. Rich IN. Published by Human Press (2015).
  39. Rich IN and Olaharski AJ. Predicting Organ Toxicity In Vitro: Bone Marrow. In: Drug Discovery Toxicology. From Target Assessment to Translational Biomarkers, Eds. Will Y, McDuffe JE, Olaharski AJ, Jeffy BD. Published by Wiley (2016).
  40. Harper H and Rich IN. Bioluminescence Potency Measurement of Cellular Therapy Products. In: Cellular Therapy: Principles, Methods, and Regulations, 2nd Edition, Eds. Areman EM and Loper K. Published by AABB.

 

Books and Monographs


  1. Rich IN, Editor: Molecular and Cellular Aspects of Erythropoietin and Erythropoiesis. NATO Advanced Science Institute, Springer Verlag. (1987).
  2. Rich IN, Lappin TRN (Editors). Molecular, Cellular and Developmental Biology of Erythropoietin and Erythropoiesis. New York Academy of Science. (1994) Vol. 718.
  3. Rich IN. (Editor). Stem Cell Protocols, No.: 1235 in the Method in Molecular Biology Series of Springer Protocols published by Human Press (2015).  

 

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